Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 100mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Adenosine 5'-diphosphate | 58-64-0 | 99.5% | 427.20 | 25MG
Adenosine 5'-diphosphate | 58-64-0 | 99.5% | 427.20 | 25MG
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 559.32 g·mol^-1 | C15H23N5O14P2 | 10 MG
Adenosine 5'-diphosphoribose is a nucleoside diphosphate reagent used in biochemical research. It functions as a metabolite and signaling molecule in nucleotide metabolism and is supplied as a solid for laboratory assays and enzymology.
- Applicable to studies of nucleotide signaling and enzymatic activity.
- Suitable for use in biochemical assays and cellular experiments.
- Supplied in small research quantities (e.g., 10 mg) for assay development.
- Identified by CAS, molecular formula, and molecular weight for accurate reference.
- Intended for research use only; not for diagnostic or clinical use.
![Alkali Scientific ATP [Adenosine 5' triphosphate, disodium salt trihydrate], 25 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660197.jpg-250.jpg)
Alkali Scientific ATP [Adenosine 5' triphosphate, disodium salt trihydrate], 25 G
ATP (Adenosine 5' triphosphate, disodium salt trihydrate) in its 25G form is a highly concentrated reagent used for extensive laboratory applications in energy transfer studies, enzymatic reactions, and cell signaling research. This energy molecule is critical in facilitating cellular processes like muscle contraction, active transport, and biochemical pathways in living cells. ATP is used extensively in experiments requiring rapid energy release, including PCR (polymerase chain reaction), in vitro transcription, and protein synthesis assays. Its high purity ensures reliable results in biochemical assays and is a key reagent for studying cellular metabolism, enzymatic activity, and mitochondrial function.
Alkali Scientific Coenzyme A Trilithium Salt, 25 Mg
Coenzyme A Trilithium Salt, 25MG, is a highly purified chemical reagent used in biochemical research for studies related to enzyme catalysis and metabolism. Coenzyme A (CoA) plays a key role in the metabolism of fatty acids, carbohydrates, and amino acids, and is essential for energy production in cells. The trilithium salt form offers enhanced stability and solubility for laboratory applications. This reagent is often used in enzyme assays, metabolic pathways research, and in the preparation of coenzyme derivatives for further chemical modification. It is also used in pharmaceutical development and drug design related to metabolic disorders and energy metabolism.
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 5 MG
Sonidegib diphosphate, also known as Erismodegib diphosphate, is a potent and selective Smoothened (Smo) antagonist. It works by directly interacting with Smo to reduce the expression of downstream Hedgehog (Hh) signaling targets. This compound has shown dose-related antitumor activity in medulloblastoma mouse models, effectively inhibiting tumor growth and causing regression at higher doses. It is for research use only.
- Potent and selective Smo antagonist
- Interacts directly with Smo to reduce expression of downstream Hh signaling targets
- Inhibits the Hh pathway in CD34+ chronic phase chronic myeloid leukemia (CML) cells
- Reduces the number and self-renewal capacity of CML leukemia stem cells (LSC)
- Demonstrates dose-related antitumor activity in medulloblastoma allograft mouse models
- Significantly inhibits tumor growth and affords regression at higher doses
Medchemexpress LLC ATP Citrate Lyase Antibody (YA596) | 121 kDa | 10 UL
ATP Citrate Lyase Antibody (YA596) is a rabbit host antibody reactive with human and mouse samples. It is supplied as a liquid at 1 mg/mL and is suitable for various applications including Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunoprecipitation, and Flow Cytometry.
- Rabbit host antibody
- Reacts with human and mouse samples
- Supplied as a liquid at 1 mg/mL
- Applications: Western Blot, ICC/IF, IHC-P, IP, FC
- Formulated in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol
- Contains 0.05% Sodium Azide preservative
- Stored at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
Cambridge Isotope Laboratories Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Medchemexpress LLC 8-azidoadenosine 5'-triphosphate trisodium | 00-00-0 | 98.1% | 614.14 | C10H12N8Na3O13P3 | 5 MG
8-Azido-ATP trisodium is a photoreactive adenosine triphosphate analog supplied as the trisodium salt in solution. It is used to photo-crosslink and label ATP-binding proteins and serves as an azide-containing reagent for click chemistry and protein-nucleotide interaction studies.
- Photoreactive ATP analog for photo-crosslinking and protein identification.
- Azide functionality enables copper-catalyzed and strain-promoted click chemistry.
- Supplied as trisodium salt in a solution form suitable for direct use or dilution.
- High reported purity, supporting reproducible experimental results.
- Storage guidelines support frozen stock solutions for long-term stability.
Medchemexpress LLC L-adenosine | 3080-29-3 | MFCD01075784 | 99.8% | 267.24 g/mol | C10H13N5O4 | 50 MG
L-adenosine is an enantiomeric analog of adenosine used as a research reagent and a weak adenosine deaminase (ADA) inhibitor (reported Ki = 385 μM). It is supplied as a high-purity solid for studies of adenosine uptake, accumulation, and ADA-related metabolism.
- High purity - 99.82% (reported).
- Suitable for adenosine uptake and accumulation studies.
- Weak ADA inhibitor (Ki ≈ 385 μM).
- Available as a 50 MG solid; additional pack sizes and DMSO solutions are offered.
- Molecular weight 267.24 g/mol; formula C10H13N5O4.
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 100 MG
Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC), is a nucleoside diphosphate that activates the adenosine 5'-triphosphate-sensitive K+ channel. It functions as an iron mobilizer by forming a complex with hepcidin, thereby inhibiting the hepcidin-ferroportin (FPN) interaction and modulating the IL-6/stat-3 pathway. This compound can ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4 and is suitable for AI research.
- Activates adenosine 5'-triphosphate-sensitive K+ channel.
- Functions as an iron mobilizer.
- Inhibits hepcidin-ferroportin interaction.
- Modulates the IL-6/stat-3 pathway.
- Ameliorates Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4.
- Suitable for research applications.
Medchemexpress LLC Adenosine 5'-diphosphoribose | 20762-30-5 | 559.32 | C15H23N5O14P2 | 50 MG
Adenosine 5'-diphosphoribose (ADP ribose) is a nucleotide metabolite supplied as a research reagent for biochemical and analytical studies. It is used to investigate NAD+ metabolism, TRPM2 channel activation, and ADP-ribosylation pathways. Intended for research use only.
- Nucleotide metabolite for biochemical and analytical assays.
- Molecular formula C15H23N5O14P2; molecular weight 559.32.
- Used in studies of NAD+ metabolism, TRPM2 activation, and ADP-ribosylation.
- Manufacturer datasheet lists pack sizes 1 mg, 5 mg, and 10 mg.